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A photo of the NSR, ZPE’s replacement option for the Cisco ISR 4431 EOL models.
The Cisco 4351 comes from the Integrated Services Router (ISR) product line of enterprise branch WAN solutions. The ISR 4351 works with Cisco’s software-defined wide area networking (SD-WAN) solution and the Cisco Digital Network Architecture (Cisco DNA) infrastructure management platform. It has a modular design that uses removable Network Interface Modules (NIMs) to extend its capabilities, for example, adding out-of-band (OOB) serial console management for up to 60 devices. Cisco announced end-of-life (EOL) dates for the entire ISR 4300 product line in 2022, and the 4351 is already past the end-of-sale and last ship dates. This guide compares Cisco 4351 EOL replacement options and discusses the innovative features and capabilities offered by modern, Gen 3 branch networking solutions. Click here for a list of Cisco ISR 4351 EOL products and replacement SKUs.

Upcoming Cisco ISR 4351 EOL dates

  • November 6, 2024 – End of routine failure analysis, end of new service attachment
  • August 31, 2025 – End of software maintenance releases and bug fixes
  • February 5, 2028 – End of service contract renewal
  • November 30, 2028 – Last date of support.

Looking to replace a different Cisco EOL model? Read our guides Cisco ISR 4431 EOL Replacement Guide and Cisco ISR EOL Replacement Options.

Cisco 4351 EOL replacement options

Cisco ISR 4351 (EOL)

Cisco Catalyst C8300

Nodegrid NSR

Out-of-band (OOB) management

Gen 1 OOB

Gen 2 OOB

Gen 3 OOB

Extensibility

Integrates with Cisco partners only

Integrates with Cisco partners only

Supports virtualization, containers, and integrations

Automation

• Policy-based automation

• Cloud-based automated device provisioning (ZTP)

• Automated deployment of network services (Cisco DNA)

• Policy-based automation

• Cloud-based automated device provisioning (ZTP)

• Automated deployment of network services (Cisco DNA)

• Zero Touch Provisioning (ZTP) via LAN/DHCP, WAN/ZPE Cloud, USB

• Auto-discovery via network scan and custom probes

• Integrated orchestration and automation:

  ◦ Puppet

  ◦ Chef

  ◦ Ansible

  ◦ RESTful

  ◦ ZPE Cloud

  ◦ Nodegrid Manager

Security

• Intrusion prevention

• Cisco Umbrella Branch

• Encrypted traffic analytics

• IPSec tunnels

• DMVPN

• FlexVPN

• GETVPN

• Content filtering

• NAT

• Zone-based firewall

• Intrusion prevention

• Cisco Umbrella Branch

• Encrypted traffic analytics

• IPSec tunnels

• DMVPN

• FlexVPN

• GETVPN

• Content filtering

• NAT

• Zone-based firewall

• Edgified, hardened device with BIOS protection, TPM 2.0, UEFI Secure Boot, Signed OS, Self-Encrypted Disk (SED), Geofencing

• X.509 SSH certificate support, 4096-bit encryption keys

• SDLC validated by Synopsys to eliminate CVEs and vulnerabilities from third-party integrations

• Selectable cryptographic protocols for SSH and HTTPS (TLSv1.3)

• SSL VPN (Client and Server)

• IPSec, WireGuard, strongSwan with support for multi-sites

• Local, AD/LDAP, RADIUS, TACACS+, and Kerberos authentication

• SAML support via Duo, Okta, Ping Identity

• Local, backup-user authentication support

• User-access lists per port

• Fine grain and role-based access control (RBAC)

• Firewall - IP packet and security filtering, IP forwarding support

• Two-factor authentication (2FA) with RSA and Duo

Hardware Services

• Serial console ports

• USB console ports

• IP management ports

• Voice functionality

• Compute module

• Serial console ports

• USB console ports

• Voice functionality

• Serial console ports

• USB console ports

• IP management ports

• PDU management

• IPMI device management

• (Optional) Compute module

• (Optional) Storage module

Network services

• Cisco SD-WAN software

• WAN optimization

• AppNAV

• Application visibility and control

• Multicast

• Overlay Transport Virtualization (OTV)

• Ethernet VPN (EVPNoMPLS)

• IPv6 support

• Cisco SD-WAN software

• WAN optimization

• AppNAV

• Application visibility and control

• Multicast

• Overlay Transport Virtualization (OTV)

• Ethernet VPN (EVPNoMPLS)

• IPv6 support

• IPv4 / IPv6 Support

• Embedded Layer 2 Switching

• VLAN

• Layer 3 Routing

• BGP

• OSPF

• RIP

• QoS

• DHCP (Client and Server)

Operating System

Cisco IOS

Cisco IOS

Built-in x86-64bit Linux Kernel Nodegrid OS

CPU

Multi-Core processor

Multi-Core processor

Intel x86-64 Multi-Core

Storage

4GB-8GB Flash memory

16GB M.2 SSD storage

32GB FLASH (mSATA SSD) (Upgradeable) Self-Encrypted Drive (SED)

RAM

4GB-8GB DRAM

8GB DRAM

8GB DDR DRAM (Upgradeable)

Size

2RU

2RU

1RU

The Cisco Catalyst C8300

Cisco recommends replacing the 4351 with the Catalyst C8300, but this platform does not go far enough to improve upon the limitations of the EOL model. For instance, both the ISR 4351 and the Catalyst C8300 replacement models are 2RU devices, making them too large for some branch and edge deployment use cases where space is limited. Additionally, while both platforms integrate with some of Cisco’s third-party partners (like ThousandEyes), Cisco is a closed ecosystem that may not support all the management, automation, and security tools needed to support an enterprise branch. Additionally, Cisco’s DNA software may not be able to control mixed-vendor infrastructure, leaving critical coverage gaps.

The Nodegrid Net SR (NSR)

A diagram showing all the capabilities of the Nodegrid NSR. ZPE Systems offers a range of enterprise branch network management solutions called Nodegrid that serve as an upgrade to Cisco 4351 EOL models. In particular, the Nodegrid Net Services Router (NSR) makes an ideal 4351 replacement due to its modular design, which can be extended with expansion modules for functionality like edge compute, PoE, USB OCP debug, and third-generation (or Gen 3) out-of-band management. Gen 3 OOB allows teams to deploy third-party automation and orchestration workflows over the OOB network to streamline branch provisioning, management, and recovery. Gen 3 OOB ensures 24/7 remote access to branch infrastructure even during network outages, provides a safe environment to recover from ransomware and other breaches, and keeps resource-intensive management workflows from bogging down the production network.

Want to see how Nodegrid stacks up against Cisco’s 4351 EOL replacement options? Click here to download the services routers comparative matrix.

Pictures of the compute module and Ethernet PoE module for the Nodegrid NSR. All Nodegrid solutions are completely vendor-neutral, integrating with or even directly hosting third-party software and extending complete visibility and control to legacy and mixed-vendor infrastructure. Nodegrid is essentially a branch-in-a-box, allowing companies to deploy infrastructure automation, network orchestration, branch security, and more on a single device that’s 1RU or smaller. Plus, this entire toolkit is available on an isolated, out-of-band network, ensuring remote teams have 24/7 access to keep business operating even during outages and ransomware attacks for superior network resilience.

Ready to replace your Cisco 4351 EOL solutions?

Nodegrid delivers vendor-neutral, branch-in-a-box solutions that streamline remote infrastructure management while improving network resilience. See our Cisco 4351 EOL replacement SKUs below or contact ZPE Systems for help choosing the right Nodegrid solution for your business.

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Cisco 4351 EOL replacement SKUs

Cisco 4351 EOL Product SKUs

In-Scope Features

Nodegrid Replacement Product SKUs

ISR4351-AX/K9

ISR4351-DNA

ISR4351-PM20

ISR4351-SEC/K9

ISR4351/K9

ISR4351-V/K9

ISR4351-VSEC/K9

Serial Console Module, Routing, 16 serial ports

ZPE-NSR-816-DAC with 1 x 16 port serial module 1 x ZPE-NSR-16SRL-EXPN

ISR4351-AX/K9

ISR4351-DNA

ISR4351-PM20

ISR4351-SEC/K9

ISR4351/K9

ISR4351-V/K9

ISR4351-VSEC/K9

Serial Console Module, Routing, 32 serial ports

ZPE-NSR-816-DAC with 2 x 16 port serial module 2 x ZPE-NSR-16SRL-EXPN

ISR4351-AX/K9

ISR4351-DNA

ISR4351-PM20

ISR4351-SEC/K9

ISR4351/K9

ISR4351-V/K9

ISR4351-VSEC/K9

Serial Console Module, Routing, 48 serial ports

ZPE-NSR-816-DAC with 3 x 16 port serial module 3 x ZPE-NSR-16SRL-EXPN

ISR4351-AX/K9

ISR4351-DNA

ISR4351-PM20

ISR4351-SEC/K9

ISR4351/K9

ISR4351-V/K9

ISR4351-VSEC/K9

Serial Console Module, Routing, 60 serial ports

ZPE-NSR-816-DAC with 4 x 16 port serial module 4 x ZPE-NSR-16SRL-EXPN

80 serial port option – no Cisco equivalent

Serial Console Module, Routing, 80 serial ports

ZPE-NSR-816-DAC with 5 x 16 port serial module 5 x ZPE-NSR-16SRL-EXPN

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